From the floor in Xi'an: 9 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Archive — December 2024
Page 2 of 5 of this archive, newest first.
Norway caps liraglutide prescribing to 9 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
SURMOUNT-OSA extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Poland pharmacy body issues counselling standards for liraglutide initiation
The evidence base is thin and the document says so, which is to its credit.
Freezing a reconstituted vial: the ice-water interface problem
An in-use period is established by a dedicated study on a specific formulation in a specific container at a specific concentration. Borrowing one from a marketed product is…
Rapid weight loss moves eight analytes for reasons that have nothing to do with the drug
Three different explanations for the same abnormal number, and how to tell them apart.
Argentina declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
Inspectors cite Calder Vale Peptides of Skipton over sterility assurance
The observation that closes a facility is rarely the dramatic one.
What the new the United Arab Emirates guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The 9-day notice: how a compounding wind-down works in Singapore
The document is four pages. Three of them are about dates.
Oxidation, and the peroxide that came in with the surfactant
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Benzyl alcohol is a preservative, not a sterilising agent
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
Least significant change: the number your body-composition printout omits
The compartment called lean mass contains water, glycogen, viscera and skin. Only some of it is the tissue anybody is worried about.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
A supplier suspends shipping to New Zealand after 21 consecutive customs detentions
The route did not close because of a rule about peptides.
SURMOUNT-3 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Antiemetics, laxatives and the thin literature underneath them
Constipation is the most tractable of the effects and the most consistently under-managed.
Halvard & Pike Apothecary of Portland, Maine closes after 11 years
A proper account of an operation that existed, and of what closing it cost.
What the new South Africa guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
SURPASS-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Australia caps tirzepatide prescribing to 17 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
HbA1c and its lag: what a result three months old is telling you
What the SURPASS and STEP programmes reported, with the estimands and the baseline values stated.
One method is one opinion
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
The 13-day notice: how a compounding wind-down works in South Korea
The document is four pages. Three of them are about dates.
Halvard & Pike Apothecary of Portland, Maine closes after 12 years
A proper account of an operation that existed, and of what closing it cost.
Independent analysis puts a ERP liraglutide lot at 99.4%, against 98.3% on the certificate
The result is unremarkable. What the report states alongside it is not.
CPC names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The limits of mechanism: why receptor data will not tell you who responds
A catalogue of open questions, with an assessment of how likely each is to be resolved.
Maintenance dosing: what is licensed, what is practised, and what is evidenced
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
TRIUMPH-1 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Electrospray, MALDI, and the choice that shapes every spectrum after it
The two ionisation techniques in general use produce different charge distributions, different adducts and different failure modes. Certificates almost never say which was…
The visceral fat result nobody quotes, from the substudy everybody cites
The trials measured mass. Nobody measured whether the participants got weaker.
France health authority warns on falsified tirzepatide pens
Reported from the analysis, not from a warning notice.
Sweden health authority warns on falsified exenatide pens
Reported from the analysis, not from a warning notice.
Xianning export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
A shortage listing ends. 17 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
What changing your injection day does to tirzepatide exposure, and what it does not
What the pharmacokinetic data supports about dose timing, missed doses and interruption.
Reading a certificate as a document rather than as a score
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.