A year after stopping: what the trials found at the far end
The physiology of regain was described a decade before these drugs, and it explains the trajectory without invoking anything specific to them.
The archive — 2024
Page 31 of 68 of this archive, newest first.
Seasonal use, holiday use, and the honest state of the evidence
An absence of evidence is not evidence of harm. It is also not a licence.
Turnaround, cost and accreditation across the services this trade relies on
A compendial sterility test takes fourteen days of incubation and consumes the containers tested. That timescale is incompatible with the business model that made…
What an 11% rise in coupling-reagent prices does to a 15 mg vial
Follow the resin, not the catalogue.
Medutest result on a Wuhan mazdutide lot lands 3.6 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Halvard & Pike Apothecary of Portland, Maine closes after 18 years
A proper account of an operation that existed, and of what closing it cost.
Who signed this, and what did they undertake by signing it
A manufacturer’s certificate is a self-declaration. An accredited laboratory’s report is a third-party measurement. The trade prints both under one heading.
Zhuhai export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Independent analysis puts a MKM retatrutide lot at 95.5%, against 92.8% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
The quiet end of Halvard & Pike Apothecary of Portland, Maine
A proper account of an operation that existed, and of what closing it cost.
A shortage listing ends. 22 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The arithmetic behind every identity confirmation, worked in full
A peptide has a monoisotopic mass and an average mass, they differ by several daltons at this molecular size, and a certificate that does not say which it quotes cannot be…
What the tirzepatide schedule assumes about a person it has never met
We work the arithmetic out in full, because it is arithmetic and it is short.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What a 14% rise in coupling-reagent prices does to a 10 mg vial
Follow the resin, not the catalogue.
A shortage listing ends. 3 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The quiet end of Halvard & Pike Apothecary of Portland, Maine
A proper account of an operation that existed, and of what closing it cost.
The batch number is the only thing connecting the page to the vial
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Eating enough protein on a suppressed appetite is an arithmetic problem before it is a nutritional one
The practical difficulty is not knowing the target. It is meeting it on an appetite that has been pharmacologically reduced by half.
Suzhou export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
The consolidator trading as Meridian Freight Partners closes after 23 years
A proper account of an operation that existed, and of what closing it cost.
What STEP 5 tells us about maintenance, and what it does not
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
Why a result on one vial says less than the trade needs it to
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.
What the new Singapore guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
A supplier suspends shipping to Ireland after 16 consecutive customs detentions
The route did not close because of a rule about peptides.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Independent analysis puts a GL Biochem tirzepatide lot at 99.2%, against 95.8% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Dose-limiting: a definition worth being strict about
Roughly four to seven per cent of trial participants discontinued for adverse events, mostly gastrointestinal, mostly during escalation. That is the empirical size of the…
Lean mass is a compartment, not a tissue
A body-composition report gives four decimal places and no confidence interval. That is the whole difficulty in one sentence.