What twenty companies say about storage, and what they have measured
What would make a difference is not a regulator. It is three lines on a certificate, all of which are already known to whoever wrote it.
The archive — 2024
Page 8 of 68 of this archive, newest first.
What has to change before a change has happened
A flag is a probability statement about a population. It is not a statement about the person holding the printout.
SWB declines, for the 21st time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a TFC semaglutide lot at 99.0%, against 96.3% on the certificate
The result is unremarkable. What the report omits is not.
The quiet end of Halvard & Pike Apothecary of Portland, Maine
A proper account of an operation that existed, and of what closing it cost.
A shortage listing ends. 4 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Why the fifth week of a dulaglutide dose feels different from the first
An accumulation model, drawn from published parameters, with its assumptions stated.
A supplier suspends shipping to Singapore after 19 consecutive customs detentions
The route did not close because of a rule about peptides.
Calder Vale Peptides of Skipton enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What a 35% rise in coupling-reagent prices does to a 10 mg vial
Follow the resin, not the catalogue.
What the older diet-and-exercise trials found in the hip
Weight loss reduces bone mineral density at load-bearing sites. Whether that translates into fractures in this population is unmeasured.
The question no chromatogram has ever answered
Purity, content, identity, sterility and endotoxin are five separate determinations. A single sheet of paper carrying one of them is not evidence about the other four.
The reproducible spectrum: the single most useful thing a report can carry
What the Journal asks for when it writes to a supplier about an identity claim, and how often it gets it.
From the floor in Nantong: 13 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Independent analysis puts a SGN mazdutide lot at 99.2%, against 96.3% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
SURMOUNT-4 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The convention nobody explains before handing over the vial
The graduation interval differs between barrel sizes, and a 1 mL barrel is frequently marked in two-unit steps. Reading one as though it were marked in single units halves…
Blind duplicates: what happens when a laboratory does not know it is being watched
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
A shortage listing ends. 21 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Medutest result on a Xi'an tirzepatide lot lands 2.1 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
What changed at FGP in November, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What the new Norway guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Deamidation, oxidation, and the two shifts worth memorising
Deamidation adds 0.98 daltons. On a low-resolution instrument at incretin molecular weights, that is inside the noise.
What the new Mexico guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
What a 22% rise in coupling-reagent prices does to a 30 mg vial
Follow the resin, not the catalogue.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Why a result on one vial says less than the trade needs it to
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
Check the vial, not the box
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.