Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Archive — January 2025
Page 2 of 5 of this archive, newest first.
Halvard & Pike Apothecary of Portland, Maine closes after 6 years
A proper account of an operation that existed, and of what closing it cost.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
WXT names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Resolution, tailing, repeatability: the arithmetic before the result
System suitability is the set of checks demonstrating that the instrument and method were performing adequately when your sample was injected. It is recorded as a matter of…
The word “confirmed” is doing an enormous amount of work on this certificate
An intact mass measurement establishes elemental composition, at best. The number of distinct sequences consistent with a given composition is astronomically large.
From the floor in Hong Kong: 23 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Saudi Arabia health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.
SGN names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
STEP 3 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The lowest effective dose is a real concept with almost no data behind it
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
The intramuscular injection nobody intended
Skin thickness at the standard injection sites is approximately two millimetres in adults and varies remarkably little with body mass. That single finding is why short…
Six words a verification badge would need to mean anything
What a verification mark would have to carry to be checkable: a date, a lot, a method, a submitter and a link to the report.
Japan caps semaglutide prescribing to 13 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at SGN in January, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What the new France guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Counter-ion, water, salt: three masses with no chromatogram
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
Japan health authority warns on falsified exenatide pens
Reported from the analysis, not from a warning notice.
GL Biochem names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A shortage listing ends. 17 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The quiet end of the relabeller trading as Vantris Bio
A proper account of an operation that existed, and of what closing it cost.
Why a dead-clean sterile filter can pass pyrogen straight through
Bacterial endotoxin is a heat-stable lipopolysaccharide from the outer membrane of Gram-negative organisms. It survives sterilisation, passes a sterilising filter, and is…
Why the bone question is harder than the muscle question
A plausible mechanism, a measurable change, and no outcome data. This is what an open question looks like.
TFC names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a WWB mazdutide lot at 98.5%, against 97.3% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
From the floor in Hong Kong: 14 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
What twenty companies say about storage, and what they have measured
Storage instructions in this market are close to uniform and almost never accompanied by the study that would justify them. Uniformity is a sign of convention, not of…
When to stop escalating and when to stop entirely
An effect is dose-limiting when it prevents adequate intake, prevents normal activity, or produces a risk of its own. Discomfort alone is not the test.
Medutest result on a Wuxi dulaglutide lot lands 2.0 points above the supplier’s stated figure
The supplier confirmed the determination and supplied the method behind its own figure inside a week.
The online reseller trading as Adamant Research Supply enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
A supplier suspends shipping to the Netherlands after 6 consecutive customs detentions
The route did not close because of a rule about peptides.
Why the compendial sterility test is a rejection test and nothing more
The compendial sterility test cannot demonstrate that a batch is sterile. It can only fail a batch that is grossly contaminated. Everything else is process validation.
The certificate says 2025. The vial in your hand does not say anything.
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
The relabeller trading as Vantris Bio closes after 16 years
A proper account of an operation that existed, and of what closing it cost.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
What a 32% rise in coupling-reagent prices does to a 5 mg vial
Follow the resin, not the catalogue.
Thiamine and the vomiting patient
What the trials measured, which in the case of micronutrients is very little.
The arithmetic of a step: what doubling a dose actually asks of you
What the published pharmacokinetics permit, what the labels state, and where the two diverge.