From the floor in Shenzhen: 8 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Archive — June 2025
Page 4 of 5 of this archive, newest first.
The ionisation line on a report is the most informative line on it
The ionisation method determines the charge states you see, the adducts you must account for, and the modifications you might destroy in the process.
Mapping a rotation that you will actually follow
A rotation scheme that is too complicated will not be followed. We describe the simple ones that are.
From cell to clinic: where the extrapolation stops being safe
Receptor pharmacology is strong on average effects and almost silent on individual variation. That gap is where most reader questions live.
The quiet end of Halvard & Pike Apothecary of Portland, Maine
A proper account of an operation that existed, and of what closing it cost.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What a 14% rise in coupling-reagent prices does to a 20 mg vial
Follow the resin, not the catalogue.
The consolidator trading as Meridian Freight Partners enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
From vial to bench: what is recorded and what is assumed
The condition on arrival is recorded by some services and not others, and it is one of the more informative lines in a report.
Units, millilitres, milligrams: three scales on one small object
We work through the arithmetic in full, because it is short, and because the errors it prevents are order-of-magnitude errors.
Halvard & Pike Apothecary of Portland, Maine closes after 24 years
A proper account of an operation that existed, and of what closing it cost.
Independent analysis puts a GGPeps liraglutide lot at 97.8%, against 93.8% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
REWIND misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Saudi Arabia pharmacy body issues counselling standards for semaglutide initiation
The evidence base is thin and the document says so, which is to its credit.
Sarcopenia is a diagnosis, not a synonym for losing lean mass
A tour of the source literatures, with an assessment of how far each legitimately reaches.
Poland caps semaglutide prescribing to 20 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Medutest result on a Xi'an orforglipron lot lands 1.0 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
STEP 1 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
How a claim degrades between the bench and the listing
Every step between the laboratory report and the product page removes information, and the badge is the last step.
Coming off: what the pharmacology permits
What a slow reduction could plausibly buy, and what it certainly cannot prevent.
Date of analysis, date of manufacture, and the gap between them
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.
Halvard & Pike Apothecary of Portland, Maine enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
A shortage listing ends. 22 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
SURPASS-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The eighteenth month, and the conversation that should have happened in the third
What the trials measured was continuation against withdrawal. What patients want to know is continuation at a lower dose, and that study has largely not been done.
Reading a certificate as a document rather than as a score
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
Inspectors cite the relabeller trading as Vantris Bio over sterility assurance
The observation that closes a facility is rarely the dramatic one.
The 21-day notice: how a compounding wind-down works in Argentina
The document is four pages. Three of them are about dates.
GL Biochem declines, for the 17th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a MKM dulaglutide lot at 99.2%, against 96.7% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
The convention nobody explains before handing over the vial
Insulin syringes are graduated in units on a convention that fixes 100 units to one millilitre. That convention says nothing about how much peptide is in a unit, and…
The figure of merit this trade chose, and the four it did not
A market that competes on one measurement will optimise that measurement. There are legitimate ways to raise a purity figure that involve no change to the product at all.
Janoshik result on a Nantong mazdutide lot lands 0.9 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
What a 26% rise in coupling-reagent prices does to a 20 mg vial
Follow the resin, not the catalogue.
FLOW extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Janoshik result on a Wuxi semaglutide lot lands 2.4 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
The lead-in, the randomisation, and the year that followed
A withdrawal trial answers a narrower question than it appears to. This piece states which question.
Hydrolysis, isomerisation, and the arithmetic of a broken bond
Deamidation, oxidation, aggregation and hydrolysis account for nearly all of what happens to a peptide over time. Each has a characteristic residue, a characteristic…
Independent analysis puts a SGN orforglipron lot at 96.1%, against 93.2% on the certificate
The result is unremarkable. What the report omits is not.