From the floor in Tianjin: 9 posters, one theme
Reported from the sessions, and from the two hours afterwards.
TheCompound Journal
Reporting on incretins, compounding & the peptide supply chain
Page 37 of 68 of this archive, newest first.
Reported from the sessions, and from the two hours afterwards.
The document is four pages. Three of them are about dates.
Follow the resin, not the catalogue.
Trial discontinuation figures are a floor, not an estimate: trial populations are supported in ways ordinary patients are not.
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The evidence base is thin and the document says so, which is to its credit.
Reported from the sessions, and from the two hours afterwards.
Efficacy was never the question in this appraisal. Duration of treatment was.
Three randomised withdrawal designs have tested what happens when treatment stops. Their results are consistent and they are consistently misreported.
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
We asked the four independent testing services what standards they run against and what suitability criteria they apply. The answers are printed.
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The route did not close because of a rule about peptides.
The observation that closes a facility is rarely the dramatic one.
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
A small number of serious gastrointestinal events occur in people taking these drugs. Distinguishing them from the expected effect profile is the most consequential…
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
The document is four pages. Three of them are about dates.
Follow the resin, not the catalogue.
The supplier has not disputed the finding. It has not explained the gap either.
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
Parts per million sound impressive until they are converted into daltons at the molecular weight of the thing being measured.
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Efficacy was never the question in this appraisal. Duration of treatment was.
Reported from the sessions, and from the two hours afterwards.
We submitted vials for endotoxin determination and report the results, the method and the laboratory, because a pyrogen figure without a method is as empty as a purity…
What the renal and hepatic outcome programmes actually measured, and over what duration.
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Efficacy was never the question in this appraisal. Duration of treatment was.