The steps get smaller as the ladder gets higher, and that is deliberate
What the published pharmacokinetics permit, what the labels state, and where the two diverge.
The archive — 2025
Page 51 of 68 of this archive, newest first.
What STEP 8 tells us about maintenance, and what it does not
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
SURPASS-3 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Saudi Arabia health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
From the floor in Qingdao: 3 posters, one theme
Reported from the sessions, and from the two hours afterwards.
The advice is mostly reasonable. The certainty is not earned.
The gap between a defensible recommendation and a confident one is where most of the harm in this subject lives.
LAL, kinetic chromogenic, recombinant factor C: three ways to the same figure
We submitted vials for endotoxin determination and report the results, the method and the laboratory, because a pyrogen figure without a method is as empty as a purity…
What a 27% rise in coupling-reagent prices does to a 2 mg vial
Follow the resin, not the catalogue.
Singapore caps dulaglutide prescribing to 15 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
A shortage listing ends. 9 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The cake is a record of the cycle that made it
Lyophilisation does not stop degradation. It slows every pathway by removing the solvent that most of them require, and the residue of solvent that remains sets the rate.
The header, the table and the signature block
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
Ireland pharmacy body issues counselling standards for liraglutide initiation
The evidence base is thin and the document says so, which is to its credit.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
The online reseller trading as Adamant Research Supply closes after 19 years
A proper account of an operation that existed, and of what closing it cost.
The 28-day notice: how a compounding wind-down works in Germany
The document is four pages. Three of them are about dates.
Three receptors, one peptide: the design problem behind triple agonism
Head-to-head data exists for some of these comparisons and not for others. This piece says which.
The mechanism behind the mechanism
A single drug producing both constipation and diarrhoea looks contradictory until the motility data is read properly.
What the new Singapore guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
From the floor in Nantong: 15 posters, one theme
Reported from the sessions, and from the two hours afterwards.
Medutest result on a Tianjin semaglutide lot lands 2.4 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
What changed at JEEP in April, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Why a result on one vial says less than the trade needs it to
What a laboratory can and cannot know about the provenance, storage history and representativeness of what lands on its bench.
SURMOUNT-OSA was built to answer the stopping question, and it did
The evidence on stopping is better than the evidence on almost anything else in this field, because somebody deliberately randomised it.
Five lines that would change what a certificate is worth
The Journal wrote to twenty companies asking five specific questions about sterility assurance. We report the response rate, the substance and the refusals.
The Netherlands pharmacy body issues counselling standards for tirzepatide initiation
The evidence base is thin and the document says so, which is to its credit.
The relabeller trading as Vantris Bio enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
The Netherlands health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
Hangzhou export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.