The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
Archive — March 2026
Page 4 of 5 of this archive, newest first.
A shortage listing ends. 23 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Tianjin export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Endotoxin is not a microorganism, and killing the bacteria does not remove it
Three compendial method families are in routine use and a fourth, based on a recombinant enzyme rather than crab lysate, is now compendial in its own right.
What the trials monitored, and what that implies about routine practice
What the pivotal programmes measured and how often, which is a more defensible template than most published monitoring schedules.
A supplier suspends shipping to Switzerland after 17 consecutive customs detentions
The route did not close because of a rule about peptides.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.
VendorInvestigate result on a Chengdu tirzepatide lot lands 3.4 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
STEP 2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
One receptor, several signals: the case for reading semaglutide as a biased agonist
A tour of what happens in the thirty seconds after binding, and why it matters at week thirty.
Accreditation, scope, and the question nobody asks PeptideMeter
A manufacturer’s certificate is a self-declaration. An accredited laboratory’s report is a third-party measurement. The trade prints both under one heading.
The 29-day notice: how a compounding wind-down works in India
The document is four pages. Three of them are about dates.
The consolidator trading as Meridian Freight Partners closes after 24 years
A proper account of an operation that existed, and of what closing it cost.
The United Kingdom health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
STEP 5 misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
How a peptide that lasts seven days binds a receptor that recycles in minutes
What the in-vitro data supports, what it does not, and where the extrapolation to a person begins.
What a reference standard is, and what an in-house standard is not
Matching a retention time against a standard is evidence of consistency, not proof of identity. Two different species can elute at the same time on one method.
The same signature, the same peak, three different batches
A blank certificate with the numbers left editable is an ordinary internal document. Its circulation as a finished record is the problem.
PeptideMeter result on a Wuhan mazdutide lot lands 2.3 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What changed at SGN in March, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The submitted sample: the weakest link in the whole system
What a laboratory can and cannot know about the provenance, storage history and representativeness of what lands on its bench.
Independent analysis puts a SGN survodutide lot at 95.6%, against 93.1% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
The quiet end of Calder Vale Peptides of Skipton
A proper account of an operation that existed, and of what closing it cost.
A shortage listing ends. 24 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
What a 23% rise in coupling-reagent prices does to a 2 mg vial
Follow the resin, not the catalogue.
Same material, different gradients, different answers
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
A unit is not a dose, and it never was
Insulin syringes are graduated in units on a convention that fixes 100 units to one millilitre. That convention says nothing about how much peptide is in a unit, and…
Nigeria caps dulaglutide prescribing to 18 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Inspectors cite the online reseller trading as Adamant Research Supply over sterility assurance
The observation that closes a facility is rarely the dramatic one.
The 12-day notice: how a compounding wind-down works in Italy
The document is four pages. Three of them are about dates.
QST declines, for the 3rd time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Reading the mazdutide titration schedule as a regulatory artefact
What the regulatory dossiers actually contain on dose selection is remarkably thin, and worth knowing before treating the ladder as settled science.
The skeleton responds to load, and load is falling
What the Journal would want measured before treating this as settled in either direction.
Italy caps exenatide prescribing to 19 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
SURMOUNT-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
SURMOUNT-2 extension data: what happens after the trial stops
A design note rather than a result: what the comparator was, and what that permits you to conclude.
Holidays, surgery, sickness: interruption in practice
Supply interruption is the commonest cause of unplanned re-titration in this market, and it is almost never framed that way.
The degradation product that elutes underneath the parent peak
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
Spain health authority warns on falsified exenatide pens
Reported from the analysis, not from a warning notice.