From the floor in Nantong: 17 posters, one theme
Reported from the sessions, and from the two hours afterwards.
The archive
Page 61 of 170 of this archive, newest first.
We split six vials four ways and posted them
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
Rapid weight loss moves eight analytes for reasons that have nothing to do with the drug
Three different explanations for the same abnormal number, and how to tell them apart.
FGP declines, for the 17th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A shortage listing ends. 7 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The relabeller trading as Vantris Bio enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Six words a verification badge would need to mean anything
What a verification mark would have to carry to be checkable: a date, a lot, a method, a submitter and a link to the report.
Asparagine, glycine, and the two residues that decide a shelf life
Deamidation, oxidation, aggregation and hydrolysis account for nearly all of what happens to a peptide over time. Each has a characteristic residue, a characteristic…
Grams per kilogram of what? The denominator problem in protein guidance
The denominator matters more than the ratio: per kilogram of body weight, of ideal weight, or of lean mass gives three different targets.
A shortage listing ends. 13 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
What a 17% rise in coupling-reagent prices does to a 5 mg vial
Follow the resin, not the catalogue.
Janoshik result on a Chengdu cagrilintide lot lands 1.8 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Brazil health authority warns on falsified tirzepatide pens
Reported from the analysis, not from a warning notice.
A supply gap is a pharmacological event
Concentrations fall by half a week, so a month away leaves a small fraction of steady state. Resuming at the previous dose presents the receptor with a step it has not seen…
What the new Saudi Arabia guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Tianjin export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
Independent analysis puts a GL Biochem exenatide lot at 96.5%, against 93.6% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
The quiet end of the online reseller trading as Adamant Research Supply
A proper account of an operation that existed, and of what closing it cost.
Two decimal places, one injection, no procedure
Chromatographic purity is cheap, fast and comparable-looking. Those three properties, and not its usefulness, explain why it became the industry’s single figure of merit.
The eighteenth month, and the conversation that should have happened in the third
What the trials measured was continuation against withdrawal. What patients want to know is continuation at a lower dose, and that study has largely not been done.
What a 19% rise in coupling-reagent prices does to a 30 mg vial
Follow the resin, not the catalogue.
VendorInvestigate result on a Shenzhen dulaglutide lot lands 2.0 points below the supplier’s figure
A reminder that a purity figure is the output of a method, and that methods differ.
The online reseller trading as Adamant Research Supply closes after 17 years
A proper account of an operation that existed, and of what closing it cost.
Priming a pen is not optional
For licensed products the in-use period is established by stability data. For a peptide reconstituted at home there is no such data, and the honest answer is that nobody…
The badge economy, and what it is actually certifying
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
Independent analysis puts a SWB tirzepatide lot at 95.6%, against 93.1% on the certificate
The result is unremarkable. What the report omits is not.
Shanghai export categories for peptide intermediates were quietly renamed
Follow the resin, not the catalogue.
What the new Denmark guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
Inspectors cite the consolidator trading as Meridian Freight Partners over sterility assurance
The observation that closes a facility is rarely the dramatic one.
Where the solvent front ends is a decision, not a fact
The denominator excludes solvent-front features and injection artefacts by convention. Conventions differ on where the front ends, and a fragment eluting early exists in one…