A supplier suspends shipping to Switzerland after 17 consecutive customs detentions
The route did not close because of a rule about peptides.
TheCompound Journal
Reporting on incretins, compounding & the peptide supply chain
The Supply Chain Dispatch
The route did not close because of a rule about peptides.
One of the suppliers the Journal tracks has suspended shipping to India following a run of consignments detained at the border. No statement has been published; the suspension is visible only in the checkout process, which no longer accepts addresses in that market. We have written to ask whether it is permanent and whether affected customers are being refunded.
Transit times on the lane moved from a median of nine days to a median of 13. Phase-change cold packs of the type commonly used in this trade are typically specified for 72 to 120 hours depending on configuration and ambient profile, which puts a substantial fraction of these shipments outside specification for the majority of the journey.
Transit times on the lane moved from a median of nine days to a median of 13. Phase-change cold packs of the type commonly used in this trade are typically specified for 72 to 120 hours depending on configuration and ambient profile, which puts a substantial fraction of these shipments outside specification for the majority of the journey.
Every one of the twenty companies in the Journal’s dossier programme now ships with a temperature indicator in the carton, which is not true of the wider market. On our own purchasing record, an unindicated parcel is not a parcel that stayed cold; it is a parcel about which nothing is known. Suppliers that require indicator evidence for a replacement claim while shipping no indicator have constructed an unfalsifiable position.
Nkosana Dube, pharmaceutical procurement adviser, said customs holds are the unbudgeted risk. "A pack qualified for seventy-two hours meets a four-day queue and nobody is told. The paperwork problem and the temperature problem are one problem."The Journal is collecting temperature-indicator readings from readers on this lane. Photographs of an indicator with a tracking number are usable; recollections are not.
The route did not close because of a rule about peptides.
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
The route did not close because of a rule about peptides.
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
The absence of microbiological capability in this market is a commercial fact with a straightforward explanation, and it is worth understanding before blaming anybody for it.
Two signatures — one who performed the work, one who approved its release — are the ordinary regulated convention and are almost unknown here.