A certificate is a snapshot, and peptides do not stand still
A document is only as good as the chain that connects it to the material, and most chains here are two or three links longer than the paperwork admits.
Orla McCaffrey
Page 5 of 6 of this archive, newest first.
Archive — page 5
107 piecesTwenty-eight days is a number from somebody else’s product
Bacteriostatic water contains benzyl alcohol at 0.9 per cent, which inhibits microbial growth in a preserved multiple-dose presentation. It does not sterilise a contaminated…
Medutest result on a Changsha survodutide lot lands 4.3 points below the supplier’s figure
A reminder that a purity figure is the output of a method, and that methods differ.
VendorInvestigate result on a Hong Kong dulaglutide lot lands 3.1 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Retest date, expiry date, and the two conventions being confused
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Medutest result on a Wuhan mazdutide lot lands 3.6 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Who signed this, and what did they undertake by signing it
A manufacturer’s certificate is a self-declaration. An accredited laboratory’s report is a third-party measurement. The trade prints both under one heading.
Independent analysis puts a SSA orforglipron lot at 95.7%, against 92.2% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
What Medutest charges to answer the pyrogen question
The masking phenomenon known as low endotoxin recovery means a formulation can return a clean result while containing endotoxin the assay cannot see.
What a batch number is supposed to mean
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.
Who signed this, and what did they undertake by signing it
What the Journal asks when a document arrives unsigned, and what the answers have been.
Who signed this, and what did they undertake by signing it
Two signatures — one who performed the work, one who approved its release — are the ordinary regulated convention and are almost unknown here.
Independent analysis puts a Homopeptide cagrilintide lot at 98.1%, against 94.7% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
Independent analysis puts a HJ orforglipron lot at 95.8%, against 93.6% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
The number at the bottom of the certificate
A purity percentage is the most quoted figure in the research-peptide trade and one of the least examined. We asked four laboratories to analyse the same vial and got four…
Who signed this, and what did they undertake by signing it
What the Journal asks when a document arrives unsigned, and what the answers have been.
Four ways a peptide comes apart
Deamidation, oxidation, aggregation and hydrolysis account for nearly all of what happens to a peptide over time. Each has a characteristic residue, a characteristic…
A tested vial is evidence about a vial
The condition on arrival is recorded by some services and not others, and it is one of the more informative lines in a report.
The batch number is the only thing connecting the page to the vial
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Who signed this, and what did they undertake by signing it
Two signatures — one who performed the work, one who approved its release — are the ordinary regulated convention and are almost unknown here.