VendorInvestigate result on a Shanghai mazdutide lot lands 2.8 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
Analytics
Page 12 of 25 of this archive, newest first.
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A vial can be 99.4 per cent pure and not sterile in the same afternoon
The Journal has read several hundred certificates from twenty companies. We set out what the documents actually cover, and what a reader is filling in from imagination.
Independent analysis puts a JEEP retatrutide lot at 97.1%, against 94.3% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Endotoxin is not a microorganism, and killing the bacteria does not remove it
Three compendial method families are in routine use and a fourth, based on a recombinant enzyme rather than crab lysate, is now compendial in its own right.
Independent analysis puts a TFC semaglutide lot at 97.6%, against 95.9% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
The column is a choice, and it is not a small one
We set out the parameters a method disclosure would contain, all of which are known to whoever ran the sample and none of which is commercially sensitive.
Medutest result on a Qingdao survodutide lot lands 2.7 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
VendorInvestigate result on a Xianning cagrilintide lot lands 2.6 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
Independent analysis puts a Homopeptide retatrutide lot at 98.9%, against 98.1% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Nought point nine eight of a dalton: the modification that hides in plain sight
Stereochemical inversion changes the molecule, changes its biology, and changes its mass by exactly nothing.
Independent analysis puts a ERP survodutide lot at 96.4%, against 93.7% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
Six words a verification badge would need to mean anything
The Journal does not treat a badge as evidence and states so wherever it reports one.
What counts as total, and who decided
We work through a single chromatogram twice, under two integration conventions, and show where the difference comes from.
Independent analysis puts a QYB dulaglutide lot at 99.3%, against 98.0% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Freezing a reconstituted vial: the ice-water interface problem
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
Independent analysis puts a KP liraglutide lot at 97.9%, against 97.0% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
What the paperwork is for, and who it was designed to protect
The purity figure is the least informative line on a well-constructed certificate and the only line most buyers read.
Janoshik result on a Nantong retatrutide lot lands 1.4 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
A vial can be 99.4 per cent pure and not sterile in the same afternoon
Every certificate circulating in this market answers a question about molecules. Almost none answers a question about organisms, pyrogens, or the integrity of the seal.
Independent analysis puts a WXT exenatide lot at 96.5%, against 92.6% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.