What the anaesthetists said, and then said again
What endoscopic and ultrasound studies found about residual gastric content, and what the aspiration data does and does not support.
Nutrition
Page 11 of 11 of this archive, newest first.
Which results should be repeated before they are investigated
What the pivotal programmes measured and how often, which is a more defensible template than most published monitoring schedules.
Why the bone question is harder than the muscle question
What the Journal would want measured before treating this as settled in either direction.
Severity grading, and the gap between a grade and an experience
Trial adverse-event tables count episodes reported to a study nurse. They are the best data we have and they systematically under-record the mundane.
What the trials counted as intolerance
We set out the questions that distinguish a symptom to manage from a dose to change.
The one-quarter rule, and the paper that took it apart
The gap between a defensible recommendation and a confident one is where most of the harm in this subject lives.
A guide to the results that will resolve themselves
Three different explanations for the same abnormal number, and how to tell them apart.
Background rates, and why they matter for attribution
Rapid weight loss by any means raises gallstone risk. Separating that from a direct drug effect requires a comparator, and the trials have one.
A guide to the results that will resolve themselves
Three different explanations for the same abnormal number, and how to tell them apart.
A guide to the results that will resolve themselves
The panel drawn during a week of vomiting is measuring the vomiting.
Why the bone question is harder than the muscle question
Weight loss reduces bone mineral density at load-bearing sites. Whether that translates into fractures in this population is unmeasured.
Pancreatitis, obstruction, gallbladder: three things nausea can be
Pancreatitis is rare, was adjudicated in the outcome programmes, and did not show the imbalance early case reports suggested.
Background rates, and why they matter for attribution
The features that should prompt urgent assessment, stated once and plainly.
The tolerability data everybody quotes and nobody reads
Almost every figure in circulation about tolerability comes from six publications. This is what they say.