The named comparison we promised two years ago
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
Purity
Chromatographic purity as a measurement: method, gradient, wavelength, integration, and reference standard.
What changed at SWB in June, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
What changed at SSA in June, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Hydrolysis, isomerisation, and the arithmetic of a broken bond
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Independent analysis puts a TFC tirzepatide lot at 98.3%, against 95.4% on the certificate
The result is unremarkable. What the report omits is not.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
BCH declines, for the 17th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a FGP exenatide lot at 95.7%, against 94.1% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
We asked four laboratories for a sterility test. Here is what came back.
Four independent services underpin confidence in this market. All four are competent at chemistry. Microbiology is a different accreditation, a different facility and a…
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Australia health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
What a split-sample exercise can establish, and what it cannot
Duplicate submissions under different names test within-laboratory repeatability, which is a different quantity from between-laboratory reproducibility.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What changed at SWB in June, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Two per cent water sounds like nothing and is not nothing
Residual moisture is measured routinely in regulated manufacture, is reported almost nowhere in this trade, and predicts long-term stability better than any other single…
Saudi Arabia health authority warns on falsified tirzepatide pens
Reported from the analysis, not from a warning notice.
Independent analysis puts a QYB semaglutide lot at 98.3%, against 96.3% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
How far back does this document actually reach?
A document is only as good as the chain that connects it to the material, and most chains here are two or three links longer than the paperwork admits.
The instrument was calibrated on Tuesday. Your sample ran on Friday.
Calibration drift is real, unremarkable, and the reason serious laboratories run internal standards.
Isobaric substitutions: identical masses, different molecules
Deamidation adds 0.98 daltons. On a low-resolution instrument at incretin molecular weights, that is inside the noise.