The dose that got you here and the dose that keeps you here
The commonest real-world strategy in this drug class is the least studied one.
Shortage listings
Page 11 of 13 of this archive, newest first.
The lowest effective dose is a real concept with almost no data behind it
Dose reduction is not withdrawal, and the trials that tested withdrawal cannot be read as testing it.
The 14-day notice: how a compounding wind-down works in Spain
The document is four pages. Three of them are about dates.
Maintenance dosing: what is licensed, what is practised, and what is evidenced
A survey of the maintenance evidence, which is shorter than the survey of the withdrawal evidence.
The 14-day notice: how a compounding wind-down works in Canada
The document is four pages. Three of them are about dates.
A shortage listing ends. 5 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
A shortage listing ends. 17 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
A shortage listing ends. 13 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
Randomised withdrawal is the cleanest design in this field and the least discussed
A withdrawal trial answers a narrower question than it appears to. This piece states which question.
A shortage listing ends. 6 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The 9-day notice: how a compounding wind-down works in Spain
The document is four pages. Three of them are about dates.
A shortage listing ends. 23 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The 11-day notice: how a compounding wind-down works in Canada
The document is four pages. Three of them are about dates.
The 24-day notice: how a compounding wind-down works in the United Kingdom
The document is four pages. Three of them are about dates.
What STEP 3 tells us about maintenance, and what it does not
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
The 12-day notice: how a compounding wind-down works in the United Arab Emirates
The document is four pages. Three of them are about dates.
Stepping down against stopping: two decisions treated as one
These agents produce no dependence and no withdrawal syndrome. What a taper would be for is therefore a real question rather than an obvious one.
A shortage listing ends. 7 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The 9-day notice: how a compounding wind-down works in Japan
The document is four pages. Three of them are about dates.
The 21-day notice: how a compounding wind-down works in New Zealand
The document is four pages. Three of them are about dates.