A supplier suspends shipping to Turkey after 4 consecutive customs detentions
The route did not close because of a rule about peptides.
Stability
Page 2 of 20 of this archive, newest first.
Choosing a needle for a subcutaneous peptide
Skin thickness at the standard injection sites is approximately two millimetres in adults and varies remarkably little with body mass. That single finding is why short…
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Aggregation: the impurity your chromatogram dissolved before it looked
We describe each pathway in enough chemical detail to explain why it is invisible to the method the trade uses, because that is the part which has practical consequences.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Adsorption, and the dose that stayed on the glass
Bacteriostatic water contains benzyl alcohol at 0.9 per cent, which inhibits microbial growth in a preserved multiple-dose presentation. It does not sterilise a contaminated…
A supplier suspends shipping to Norway after 13 consecutive customs detentions
The route did not close because of a rule about peptides.
A supplier suspends shipping to Mexico after 5 consecutive customs detentions
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Deamidation is the commonest degradation route and the hardest to see
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to Italy after 15 consecutive customs detentions
The route did not close because of a rule about peptides.
The retest date and the expiry date are not the same document
A retest date says that material should be re-examined before use. An expiry date says it should not be used. The trade uses the second word for the first concept.
Oxidation, and the peroxide that came in with the surfactant
We describe each pathway in enough chemical detail to explain why it is invisible to the method the trade uses, because that is the part which has practical consequences.
A supplier suspends shipping to Saudi Arabia after 15 consecutive customs detentions
The route did not close because of a rule about peptides.
Lipohypertrophy, and the absorption it ruins
Repeated injection into the same small area produces lipohypertrophy — thickened, rubbery subcutaneous tissue with blunted and erratic absorption. It is common, it is…
The degradation product that elutes underneath the parent peak
Deamidation, oxidation, aggregation and hydrolysis account for nearly all of what happens to a peptide over time. Each has a characteristic residue, a characteristic…
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Aseptic technique for people who were never taught it
For licensed products the in-use period is established by stability data. For a peptide reconstituted at home there is no such data, and the honest answer is that nobody…
A supplier suspends shipping to Singapore after 19 consecutive customs detentions
The route did not close because of a rule about peptides.