The one place the insulin literature and this class agree completely
Repeated injection into the same small area produces lipohypertrophy — thickened, rubbery subcutaneous tissue with blunted and erratic absorption. It is common, it is…
Syringes & units
Page 2 of 4 of this archive, newest first.
Priming a pen is not optional
For licensed products the in-use period is established by stability data. For a peptide reconstituted at home there is no such data, and the honest answer is that nobody…
What a 1 mL syringe does that a 0.3 mL syringe does not
A unit is a volume. A dose is a mass. The bridge between them is concentration, and concentration is a number somebody has to calculate.
Gauge, pain and flow rate
Skin thickness at the standard injection sites is approximately two millimetres in adults and varies remarkably little with body mass. That single finding is why short…
A unit is not a dose, and it never was
The graduation interval differs between barrel sizes, and a 1 mL barrel is frequently marked in two-unit steps. Reading one as though it were marked in single units halves…
Gauge, pain and flow rate
The insulin injection-technique literature is large, well conducted and directly transferable on questions of depth and tissue. We say where it stops transferring.
Storage after reconstitution, and the evidence behind the numbers
A needle blunts on first use. Reuse is uncomfortable, and it is a documented contributor to lipohypertrophy.
Mapping a rotation that you will actually follow
A rotation scheme that is too complicated will not be followed. We describe the simple ones that are.
Units, millilitres, milligrams: three scales on one small object
We work through the arithmetic in full, because it is short, and because the errors it prevents are order-of-magnitude errors.
From milligrams in a vial to units in a barrel
A more concentrated reconstitution means smaller injection volumes, which means larger proportional errors from graduation, dead space and technique.
Units, millilitres, milligrams: three scales on one small object
We work through the arithmetic in full, because it is short, and because the errors it prevents are order-of-magnitude errors.
A needle is a single-use instrument
Sharps disposal is a legal obligation in most jurisdictions and a safety obligation everywhere. Household waste is not a route.
How much water: the question with no single right answer
The diluent choice affects preservation and in-use period rather than the arithmetic — but the wrong choice for a multi-dose vial is a sterility decision, not a convenience…
Choosing a needle for a subcutaneous peptide
A 4 mm needle at ninety degrees without a skin pinch is adequate for essentially all adults. The persistence of 12.7 mm needles in this market is habit, not reasoning.
Mapping a rotation that you will actually follow
Repeated injection into the same small area produces lipohypertrophy — thickened, rubbery subcutaneous tissue with blunted and erratic absorption. It is common, it is…
Storage after reconstitution, and the evidence behind the numbers
Sharps disposal is a legal obligation in most jurisdictions and a safety obligation everywhere. Household waste is not a route.
How a correct calculation becomes a wrong dose
A pharmacist catches most of these in licensed practice. In this market there is no pharmacist, so the checks have to be structural.
Gauge, pain and flow rate
The insulin injection-technique literature is large, well conducted and directly transferable on questions of depth and tissue. We say where it stops transferring.
The site you keep using is the site that stops working
Lipohypertrophic tissue is less painful to inject into, which is precisely why people keep injecting into it.
Priming a pen is not optional
For licensed products the in-use period is established by stability data. For a peptide reconstituted at home there is no such data, and the honest answer is that nobody…