Gallstones during rapid weight loss: drug, or weight loss?
Pancreatitis is rare, was adjudicated in the outcome programmes, and did not show the imbalance early case reports suggested.
Archive — September 2025
Page 2 of 5 of this archive, newest first.
The limits of mechanism: why receptor data will not tell you who responds
A catalogue of open questions, with an assessment of how likely each is to be resolved.
What a 25% rise in coupling-reagent prices does to a 20 mg vial
Follow the resin, not the catalogue.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Calder Vale Peptides of Skipton closes after 9 years
A proper account of an operation that existed, and of what closing it cost.
The 14-day notice: how a compounding wind-down works in France
The document is four pages. Three of them are about dates.
Why a dry powder is a chemical reactor with the volume turned down
Residual moisture is measured routinely in regulated manufacture, is reported almost nowhere in this trade, and predicts long-term stability better than any other single…
What the new France guidance says about stopping
The evidence base is thin and the document says so, which is to its credit.
The online reseller trading as Adamant Research Supply closes after 22 years
A proper account of an operation that existed, and of what closing it cost.
South Africa health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
SELECT misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
The intramuscular injection nobody intended
Skin thickness at the standard injection sites is approximately two millimetres in adults and varies remarkably little with body mass. That single finding is why short…
Continued treatment against continued placebo: the comparison that settled it
The evidence on stopping is better than the evidence on almost anything else in this field, because somebody deliberately randomised it.
What a laboratory knows about the material it receives
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.
Calder Vale Peptides of Skipton enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Poland caps liraglutide prescribing to 14 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
What changed at WWB in September, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The shortage years, and what they taught about interruption
A supply interruption is a discontinuation with no notice, no taper and no plan. That is a distinct clinical situation.
Bacteriostatic water, sterile water, and the 0.9 per cent that makes the difference
An in-use period is established by a dedicated study on a specific formulation in a specific container at a specific concentration. Borrowing one from a marketed product is…
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Poland declines to reimburse dulaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
SELECT misses on a secondary endpoint the coverage has not mentioned
A design note rather than a result: what the comparator was, and what that permits you to conclude.
A shortage listing ends. 8 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
A vial can be 99.4 per cent pure and not sterile in the same afternoon
Purity, content, identity, sterility and endotoxin are five separate determinations. A single sheet of paper carrying one of them is not evidence about the other four.
A supplier suspends shipping to Singapore after 19 consecutive customs detentions
The route did not close because of a rule about peptides.
WXT names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The Netherlands health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.
The consolidator trading as Meridian Freight Partners closes after 17 years
A proper account of an operation that existed, and of what closing it cost.
Same mass, different molecule: why identity by mass is not identity
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
What the trial protocols permitted, and what the labels omitted
Reducing a dose is not going backwards. In a tolerability-limited class it is the mechanism by which the ceiling is found.
Do you need the top of the ladder?
What the trials measured was continuation against withdrawal. What patients want to know is continuation at a lower dose, and that study has largely not been done.
The 11-day notice: how a compounding wind-down works in Sweden
The document is four pages. Three of them are about dates.
What changed at QST in September, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Halvard & Pike Apothecary of Portland, Maine enters a consent decree and stops sterile preparation
The observation that closes a facility is rarely the dramatic one.
Side effects, cost, supply, target: four reasons with four trajectories
Cost is the modal reason for discontinuation in every dataset we have seen, and it is absent from the clinical literature.
The cake tells you something, and it is not purity
Multiple-dose vials are designed for a defined number of punctures. Nobody counts, and the elastomer does not care whether anybody counts.
What changed at CPC in September, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
A shortage listing ends. 16 pharmacies now have a business model and no legal basis for it.
The document is four pages. Three of them are about dates.
The slide that was not in the abstract
Reported from the sessions, and from the two hours afterwards.