Independent analysis puts a SSA orforglipron lot at 95.7%, against 92.2% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Analytics
Page 21 of 25 of this archive, newest first.
Page 21
The fourteen-day problem, and what it does to a commercial testing model
Endotoxin is the more tractable of the two questions, and a kinetic chromogenic determination is neither slow nor exotic. It is simply not on the menu.
PeptideMeter result on a Shenzhen semaglutide lot lands 1.9 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
Independent analysis puts a QYB mazdutide lot at 95.1%, against 91.4% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
From vial to bench: what is recorded and what is assumed
The condition on arrival is recorded by some services and not others, and it is one of the more informative lines in a report.
Check the vial, not the box
The interval between manufacture and analysis is the most under-read figure on the page, and the one most likely to matter by the time a vial is opened.
Independent analysis puts a ERP cagrilintide lot at 95.3%, against 91.4% on the certificate
The result is unremarkable. What the report omits is not.
Benzyl alcohol is a preservative, not a sterilising agent
At low concentrations a measurable fraction of peptide can adsorb to glass and plastic surfaces, and the loss is largest exactly where it is least expected.
VendorInvestigate result on a Shenzhen dulaglutide lot lands 1.9 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.
Set the threshold at a tenth of a per cent and the small impurities vanish
We work through a single chromatogram twice, under two integration conventions, and show where the difference comes from.
What Medutest charges to answer the pyrogen question
The masking phenomenon known as low endotoxin recovery means a formulation can return a clean result while containing endotoxin the assay cannot see.
Independent analysis puts a CPC orforglipron lot at 96.1%, against 94.6% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
The four testing services and the study none of them can run
What would make a difference is not a regulator. It is three lines on a certificate, all of which are already known to whoever wrote it.
The four testing services and the study none of them can run
Storage instructions in this market are close to uniform and almost never accompanied by the study that would justify them. Uniformity is a sign of convention, not of…
Independent analysis puts a CPC orforglipron lot at 95.2%, against 92.3% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Janoshik result on a Nantong exenatide lot lands 3.1 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Independent analysis puts a SGN liraglutide lot at 95.7%, against 93.4% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
The question no chromatogram has ever answered
Every certificate circulating in this market answers a question about molecules. Almost none answers a question about organisms, pyrogens, or the integrity of the seal.
How a release document is put together in a regulated plant
The purity figure is the least informative line on a well-constructed certificate and the only line most buyers read.
PeptideMeter result on a Tianjin mazdutide lot lands 4.3 points below the supplier’s figure
The supplier has not disputed the finding. It has not explained the gap either.