Why a result on one vial says less than the trade needs it to
Every third-party report in this market describes a sample somebody chose to send. That choice is outside the laboratory’s control and outside its records.
Analytics
Page 19 of 25 of this archive, newest first.
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Independent analysis puts a BCH mazdutide lot at 98.6%, against 96.0% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
VendorInvestigate result on a Guangzhou liraglutide lot lands 3.6 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Why a 0.036-dalton difference is the hardest number in peptide identity
Every instrument specification quoted in an advertisement is a best case obtained on a calibration mixture, not on a submitted vial.
Independent analysis puts a Homopeptide orforglipron lot at 99.1%, against 98.4% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
Freezing a reconstituted vial: the ice-water interface problem
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
What the nitrogen said
Peptide content is the number that tells you how much drug is in the vial. Almost nobody sells it, almost nobody buys it, and when we paid for it on nine vials the results…
Independent analysis puts a TFC mazdutide lot at 98.4%, against 95.9% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
The certificate of analysis, line by line
The purity figure is the least informative line on a well-constructed certificate and the only line most buyers read.
VendorInvestigate result on a Suzhou liraglutide lot lands 4.2 points below the supplier’s figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Independent analysis puts a SGN survodutide lot at 96.5%, against 95.8% on the certificate
The result is unremarkable. What the report omits is not.
Before anything is weighed, the peptide has to be charged
A brief and unromantic tour of the interface between a liquid sample and a vacuum.
PeptideMeter result on a Guangzhou cagrilintide lot lands 3.7 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
The question no chromatogram has ever answered
The Journal has read several hundred certificates from twenty companies. We set out what the documents actually cover, and what a reader is filling in from imagination.
The badge is about a sample. The listing is about a product.
Every step between the laboratory report and the product page removes information, and the badge is the last step.
Twenty-eight days is a number from somebody else’s product
Bacteriostatic water contains benzyl alcohol at 0.9 per cent, which inhibits microbial growth in a preserved multiple-dose presentation. It does not sterilise a contaminated…
Independent analysis puts a JEEP tirzepatide lot at 96.0%, against 92.6% on the certificate
The result is unremarkable. What the report omits is not.
LAL, kinetic chromogenic, recombinant factor C: three ways to the same figure
The limit for a parenteral product is calculable from the dose and the body weight in two lines. Almost nobody in this trade performs the calculation.
Independent analysis puts a JEEP semaglutide lot at 98.0%, against 96.9% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
Medutest result on a Changsha survodutide lot lands 4.3 points below the supplier’s figure
A reminder that a purity figure is the output of a method, and that methods differ.