TheCompound Journal
Reporting on incretins, compounding & the peptide supply chain
Page 7 of 12 of this archive, newest first.
System suitability is the set of checks demonstrating that the instrument and method were performing adequately when your sample was injected. It is recorded as a matter of…
A purity figure is silent on peptide content, on water, on counter-ion, on sterility, on endotoxin and on stability. Each of those silences has a price attached.
Trial discontinuation figures are a floor, not an estimate: trial populations are supported in ways ordinary patients are not.
The class is described as though every molecule in it did the same thing. At the receptor, they demonstrably do not.
The glucagon arm raises energy expenditure and also raises hepatic glucose output. Balancing those is the whole engineering problem.
The published ladder exists because a protocol needed a single number. Practice has never followed it exactly, and the regulatory file never assumed it would.
A result without a specification is a number. A specification without a result is a promise. Certificates in this market frequently carry one and not the other.
A market that competes on one measurement will optimise that measurement. There are legitimate ways to raise a purity figure that involve no change to the product at all.
The receptor is expressed in more tissues than the popular account allows, and that is the whole story.
System suitability is the set of checks demonstrating that the instrument and method were performing adequately when your sample was injected. It is recorded as a matter of…
An intact mass measurement establishes elemental composition, at best. The number of distinct sequences consistent with a given composition is astronomically large.
What happens to traceability when bulk material is subdivided, repackaged and relabelled two or three times before sale.
Lipohypertrophic tissue is less painful to inject into, which is precisely why people keep injecting into it.
The absences are not concealment. They are the form the trade settled on, and no buyer has ever objected.
We set out the questions that distinguish a symptom to manage from a dose to change.
Dietary measures are widely recommended, plausible on mechanism, and supported mainly by observational data and clinical experience.
The mechanism is well described. The variance is not.
The most consequential features of most certificates in this market are the tests that do not appear on them at all.
An orthogonal method separates on a different physical principle, so that species co-eluting in the first are likely to resolve in the second. Two runs of the same method at…
What the pharmacokinetic data supports about dose timing, missed doses and interruption.