What a laboratory knows about the material it receives
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
The Ledger
Page 12 of 25 of this archive, newest first.
Page 12
Two-thirds back: the extension nobody expected to be the headline
The evidence on stopping is better than the evidence on almost anything else in this field, because somebody deliberately randomised it.
The shortage years, and what they taught about interruption
Real-world persistence figures, with their definitions stated, because the definitions are doing most of the work.
Singapore declines to reimburse exenatide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
India declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
A tested vial is evidence about a vial
What a laboratory can and cannot know about the provenance, storage history and representativeness of what lands on its bench.
Six words a verification badge would need to mean anything
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
Denmark declines to reimburse liraglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
The Netherlands caps tirzepatide prescribing to 4 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Switzerland declines to reimburse liraglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
Italy caps semaglutide prescribing to 18 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
The lowest effective dose is a real concept with almost no data behind it
A survey of the maintenance evidence, which is shorter than the survey of the withdrawal evidence.
Sweden caps liraglutide prescribing to 10 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
A tested vial is evidence about a vial
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.
What STEP 8 tells us about maintenance, and what it does not
Every withdrawal trial compared full dose against nothing. The clinically interesting comparison — full dose against a reduced one — has not been randomised.
Singapore caps dulaglutide prescribing to 15 specialist centres
Efficacy was never the question in this appraisal. Duration of treatment was.
Why a result on one vial says less than the trade needs it to
What a laboratory can and cannot know about the provenance, storage history and representativeness of what lands on its bench.
SURMOUNT-OSA was built to answer the stopping question, and it did
The evidence on stopping is better than the evidence on almost anything else in this field, because somebody deliberately randomised it.
Mexico declines to reimburse semaglutide outside a specialist service
Efficacy was never the question in this appraisal. Duration of treatment was.
A design note on withdrawal trials, and why the run-in matters
The regain trajectories, arm by arm, with the estimands named.