Two ways to lift a peptide into a vacuum, and why the answer differs
The ionisation method determines the charge states you see, the adducts you must account for, and the modifications you might destroy in the process.
Purity
Page 39 of 51 of this archive, newest first.
Norway health authority warns on falsified exenatide pens
Reported from the analysis, not from a warning notice.
LAL, kinetic chromogenic, recombinant factor C: three ways to the same figure
The limit for a parenteral product is calculable from the dose and the body weight in two lines. Almost nobody in this trade performs the calculation.
WWB declines, for the 10th time, to name its synthesis house
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Everything on the page, in the order a chemist would read it
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Independent analysis puts a JEEP semaglutide lot at 98.0%, against 96.9% on the certificate
The supplier has not disputed the finding. It has not explained the gap either.
Medutest result on a Changsha survodutide lot lands 4.3 points below the supplier’s figure
A reminder that a purity figure is the output of a method, and that methods differ.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
Four ways a peptide comes apart
Reversed-phase chromatography runs in an organic, acidic mobile phase that dissociates most non-covalent aggregates on the way to the detector.
Six tells, in order of how quickly they can be checked
A blank certificate with the numbers left editable is an ordinary internal document. Its circulation as a finished record is the problem.
VendorInvestigate result on a Hong Kong dulaglutide lot lands 3.1 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
Electrospray, MALDI, and the choice that shapes every spectrum after it
A brief and unromantic tour of the interface between a liquid sample and a vacuum.
From vial to bench: what is recorded and what is assumed
A result on one vial generalises to a batch only if the vial was drawn in a way that makes it representative — and nobody records how it was drawn.
The cake is a record of the cycle that made it
Lyophilisation does not stop degradation. It slows every pathway by removing the solvent that most of them require, and the residue of solvent that remains sets the rate.
Spain health authority warns on falsified semaglutide pens
Reported from the analysis, not from a warning notice.
We split six vials four ways and posted them
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
What changed at BCH in August, and what the company will not say about it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Canada health authority warns on falsified liraglutide pens
Reported from the analysis, not from a warning notice.