The intramuscular injection nobody intended
Skin thickness at the standard injection sites is approximately two millimetres in adults and varies remarkably little with body mass. That single finding is why short…
Stability
Page 12 of 20 of this archive, newest first.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to the Netherlands after 6 consecutive customs detentions
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
The retest date and the expiry date are not the same document
We asked twenty companies three questions about stability data and print every answer, refusal and non-response.
Oxidation, and the peroxide that came in with the surfactant
We describe each pathway in enough chemical detail to explain why it is invisible to the method the trade uses, because that is the part which has practical consequences.
Everything a buyer assumes has been checked, ranked by whether it has
The absences are not concealment. They are the form the trade settled on, and no buyer has ever objected.
A supplier suspends shipping to New Zealand after 3 consecutive customs detentions
The route did not close because of a rule about peptides.
A supplier suspends shipping to Poland after 11 consecutive customs detentions
The route did not close because of a rule about peptides.
Reading a certificate for what it does not say
The most consequential features of most certificates in this market are the tests that do not appear on them at all.
Freezing a reconstituted vial: the ice-water interface problem
An in-use period is established by a dedicated study on a specific formulation in a specific container at a specific concentration. Borrowing one from a marketed product is…
Oxidation, and the peroxide that came in with the surfactant
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Benzyl alcohol is a preservative, not a sterilising agent
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
Reading a certificate as a document rather than as a score
The header identifies the batch, the table records the tests, and the footer says who is answerable. Two of the three are usually incomplete.
A supplier suspends shipping to Nigeria after 23 consecutive customs detentions
The route did not close because of a rule about peptides.
A supplier suspends shipping to Brazil after 18 consecutive customs detentions
The route did not close because of a rule about peptides.
Choosing a needle for a subcutaneous peptide
Gauge affects pain and flow rate rather than depth. A finer needle is more comfortable and slower, and with a viscous solution the difference is noticeable.
A supplier suspends shipping to Switzerland after 14 consecutive customs detentions
The route did not close because of a rule about peptides.
Check the vial, not the box
A document is only as good as the chain that connects it to the material, and most chains here are two or three links longer than the paperwork admits.
What happens in solution that does not happen in the cake
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.