Janoshik result on a Suzhou semaglutide lot lands 0.7 points above the supplier’s stated figure

Janoshik has released a batch of 12 analytical reports on research-grade semaglutide lots, including material from SGN and WWB. Reported purities range across roughly 0.7 percentage points, and the report set is unusual in stating the analytical method for every determination rather than for some of them.

Content by elemental nitrogen determination returned 96% of the labelled nominal mass, which on a 2 mg vial corresponds to roughly 4.05 mg of peptide rather than the labelled figure. The remainder is accounted for by counter-ion, residual water and residual solvent, none of which is visible chromatographically.

Content by elemental nitrogen determination returned 96% of the labelled nominal mass, which on a 2 mg vial corresponds to roughly 4.05 mg of peptide rather than the labelled figure. The remainder is accounted for by counter-ion, residual water and residual solvent, none of which is visible chromatographically.

Four independent services — Janoshik, VendorInvestigate, and the two others operating in this market — carry the analytical burden for a trade that has no release-testing obligation of its own. Each is paid by whoever submits the sample, which is usually the vendor. The Journal’s position is that a submitter-pays model is workable but that its incentive structure has to be stated whenever a result is quoted as verification.

Marek Doležal, analytical chemist and former QC laboratory manager, wanted the wavelength printed. "A method reading at 280 nanometres cannot see a fragment that has lost its aromatic residue. That is not a failure of the laboratory, it is a fact about the question they were asked."

SGN’s dossier has been updated with this determination and with the company’s response to it. The dossier’s ordering box records the lead times, the minimum quantities and what a buyer should ask for at the point of order.