Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Cold chain
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Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to Spain after 6 consecutive customs detentions
The route did not close because of a rule about peptides.
Freezing a reconstituted vial: the ice-water interface problem
At low concentrations a measurable fraction of peptide can adsorb to glass and plastic surfaces, and the loss is largest exactly where it is least expected.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Twenty-eight days is a number from somebody else’s product
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
What the sequence tells you about how a peptide will fail
The sequence predicts the failure mode. A methionine predicts oxidation; an asparagine followed by a glycine predicts deamidation; a cysteine predicts disulphide scrambling.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Asparagine, glycine, and the two residues that decide a shelf life
An isoaspartate rearrangement changes the molecule and not the mass. A method that confirms identity by molecular weight alone will report it as the parent compound.
Twenty-eight days is a number from somebody else’s product
We set out what is known, what is inferred and what is simply assumed about the fortnight after a vial is opened.
A supplier suspends shipping to France after 23 consecutive customs detentions
The route did not close because of a rule about peptides.
A supplier suspends shipping to Mexico after 23 consecutive customs detentions
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to Saudi Arabia after 19 consecutive customs detentions
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Collapse temperature, and the hour of the cycle where shelf life is lost
The physics of the drying cycle explains why some cakes are matte and full-volume and others are glassy discs, and why the difference is not cosmetic.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
What happens in solution that does not happen in the cake
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
A supplier suspends shipping to Norway after 12 consecutive customs detentions
The route did not close because of a rule about peptides.