Four ways a peptide comes apart
We describe each pathway in enough chemical detail to explain why it is invisible to the method the trade uses, because that is the part which has practical consequences.
Import & customs
Page 12 of 14 of this archive, newest first.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to Portugal after 16 consecutive customs detentions
The route did not close because of a rule about peptides.
Twenty-eight days is a number from somebody else’s product
Every degradation pathway accelerates by orders of magnitude on reconstitution, because the solvent that lyophilisation removed is the reagent most of them need.
What twenty companies say about storage, and what they have measured
A stability programme needs a protocol, defined conditions, a stability-indicating method and time. Time is the ingredient no commercial testing service can sell.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to Turkey after 22 consecutive customs detentions
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Why the customs shed is the least documented step in this trade
Degradation rates rise exponentially with temperature while an arithmetic mean adds linearly. Mean kinetic temperature is the weighting that reconciles the two, and it is…
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
What we asked twenty suppliers about stability data
We asked twenty companies three questions about stability data and print every answer, refusal and non-response.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to Spain after 6 consecutive customs detentions
The route did not close because of a rule about peptides.
A supplier suspends shipping to France after 21 consecutive customs detentions
The route did not close because of a rule about peptides.
Freezing a reconstituted vial: the ice-water interface problem
At low concentrations a measurable fraction of peptide can adsorb to glass and plastic surfaces, and the loss is largest exactly where it is least expected.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
A supplier suspends shipping to South Africa after 14 consecutive customs detentions
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.
Why summer is a documented quality problem in this trade
The route did not close because of a rule about peptides.