What counts as total, and who decided
We work through a single chromatogram twice, under two integration conventions, and show where the difference comes from.
Independent testing
Page 13 of 27 of this archive, newest first.
Independent analysis puts a QYB dulaglutide lot at 99.3%, against 98.0% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Sterility is not a percentage, which is the whole difficulty
Purity, content, identity, sterility and endotoxin are five separate determinations. A single sheet of paper carrying one of them is not evidence about the other four.
Independent analysis puts a KP liraglutide lot at 97.9%, against 97.0% on the certificate
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
What the paperwork is for, and who it was designed to protect
The purity figure is the least informative line on a well-constructed certificate and the only line most buyers read.
What the four services actually offer, test by test
A compendial sterility test takes fourteen days of incubation and consumes the containers tested. That timescale is incompatible with the business model that made…
Janoshik result on a Nantong retatrutide lot lands 1.4 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
A vial can be 99.4 per cent pure and not sterile in the same afternoon
Every certificate circulating in this market answers a question about molecules. Almost none answers a question about organisms, pyrogens, or the integrity of the seal.
Independent analysis puts a WXT exenatide lot at 96.5%, against 92.6% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Why purity is the cheapest number to flatter
The Journal has read several hundred certificates from twenty companies. The number is almost always there; the method behind it almost never is.
Janoshik result on a Guangzhou retatrutide lot lands 2.2 points below the supplier’s figure
The result is unremarkable. What the report omits is not.
Six words a verification badge would need to mean anything
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
Calibrated, qualified, accredited: three words that are not synonyms
An assay against a quantitative reference standard measures how much is present. Area per cent measures what proportion of the visible material is the parent. Only the first…
Where the solvent front ends is a decision, not a fact
Regulated pharmaceutical practice has explicit reporting, identification and qualification thresholds. This trade has none, which is why a purity figure carries no…
The specification sheet says 500,000. The report says conforms.
Calibration drift is real, unremarkable, and the reason serious laboratories run internal standards.
Leucine, isoleucine, and a difference no balance can measure
Stereochemical inversion changes the molecule, changes its biology, and changes its mass by exactly nothing.
Independent analysis puts a QSC orforglipron lot at 97.3%, against 94.6% on the certificate
A reminder that a purity figure is the output of a method, and that methods differ.
Janoshik result on a Xianning tirzepatide lot lands 1.3 points below the supplier’s figure
The Journal submitted the sample and paid for the analysis. The vendor was told in advance.
How a claim degrades between the bench and the listing
Lot-level verification with a public report is a real and achievable thing. It exists in this market, on a minority of listings.
A tested vial is evidence about a vial
Chain of custody, in a regulated setting, begins at sampling. Here it begins when the package arrives.