Same material, different gradients, different answers
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
Purity
Page 4 of 51 of this archive, newest first.
Holograms, QR codes and other things that are not verification
Reported from the analysis, not from a warning notice.
PeptideMeter result on a Changsha orforglipron lot lands 1.7 points above the supplier’s stated figure
The report states the gradient, the wavelength and the integration threshold, which is more than most.
Independent analysis puts a MKM dulaglutide lot at 98.2%, against 96.7% on the certificate
The report states the gradient, the wavelength and the integration threshold, which is more than most.
An interlaboratory comparison nobody had run
Two years ago we ran an anonymised version of this comparison and promised a named one. This is it, with every method printed in full.
What changed at TFC in April, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
HJ names the synthesis and fill sites behind its catalogue
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
The named comparison we promised two years ago
Duplicate submissions under different names test within-laboratory repeatability, which is a different quantity from between-laboratory reproducibility.
Adsorption, and the dose that stayed on the glass
Bacteriostatic water contains benzyl alcohol at 0.9 per cent, which inhibits microbial growth in a preserved multiple-dose presentation. It does not sterilise a contaminated…
What changed at Homopeptide in April, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
Independent analysis puts a MKM cagrilintide lot at 97.3%, against 95.9% on the certificate
The supplier confirmed the determination and supplied the method behind its own figure inside a week.
What changed at QST in April, and what the company says prompted it
Documentation practice is the only part of vendor quality a buyer can assess before purchase.
PeptideMeter result on a Changsha mazdutide lot lands 1.3 points above the supplier’s stated figure
A reminder that a purity figure is the output of a method, and that methods differ.
Janoshik, Medutest, PeptideMeter, VendorInvestigate: a capability audit
We asked all four services what they can determine, on what timescale, at what price, and under what accreditation. The answers are printed in full.
Two documents, two disciplines: purity and sterility are not the same trade
The Journal has read several hundred certificates from twenty companies. We set out what the documents actually cover, and what a reader is filling in from imagination.
PeptideMeter result on a Hangzhou orforglipron lot lands 0.7 points above the supplier’s stated figure
The result is unremarkable. What the report states alongside it is not.
How a release document is put together in a regulated plant
Nothing on this page is difficult. It is simply unfamiliar, and unfamiliarity is what makes a weak certificate look like a strong one.
What a diode array adds, and why the certificate never shows it
Non-chromophoric components — counter-ions, salts, some excipients — contribute mass to the vial and nothing at all to the chromatogram.
Brazil health authority warns on falsified dulaglutide pens
Reported from the analysis, not from a warning notice.
The named comparison we promised two years ago
The Journal submitted split samples from single lots to three assay services, under names unconnected to this publication, and published each method alongside each result.