Medutest result on a Suzhou semaglutide lot lands 4.3 points above the supplier’s stated figure

Medutest has released a batch of 13 analytical reports on research-grade semaglutide lots, including material from WWB and WXT. Reported purities range across roughly 4.3 percentage points, and the report set is unusual in stating the analytical method for every determination rather than for some of them.

Reported figures across the set were: highest 95.8%, lowest 92.4%, median close to the midpoint of the two. Every report in the set stated a detection wavelength, and 13 of them stated an integration threshold. The Journal has asked the laboratory to publish thresholds on all reports as a matter of routine.

Reported figures across the set were: highest 95.8%, lowest 92.4%, median close to the midpoint of the two. Every report in the set stated a detection wavelength, and 13 of them stated an integration threshold. The Journal has asked the laboratory to publish thresholds on all reports as a matter of routine.

Batch variance rather than vendor quality is the recurring finding of this programme. Across the 13 determinations the Journal has commissioned to date, within-vendor spread has been wider than between-vendor spread for two thirds of the companies tracked, which is an argument against rating any supplier on a single number.

"Ask for the suitability summary before you argue about the percentage," said Marek Doležal, analytical chemist and former QC laboratory manager. "If the tailing factor and the replicate precision are outside limits, you are arguing about arithmetic performed on an unfit separation."

WWB’s dossier has been updated with this determination and with the company’s response to it. The dossier’s ordering box records the lead times, the minimum quantities and what a buyer should ask for at the point of order.